Your First Week on a GLP-1: What to Expect and How to Prepare

Starting a GLP-1 medication like Ozempic, Wegovy, Mounjaro, or Zepbound can feel like a big step. Knowing what the first days usually look like makes it easier to settle in, and a little preparation can help you avoid the most common rough spots.

You will start on a low dose

GLP-1 medications begin at a low starting dose that is not meant to be your long-term dose. For example, Wegovy starts at 0.25 mg once a week for 4 weeks, according to its prescribing information, and Zepbound starts at 2.5 mg once a week for 4 weeks, according to its dosing guidelines. The dose then increases gradually. This slow start is designed to reduce digestive side effects, so it is normal not to notice dramatic changes right away.

What you might notice

A smaller appetite

Many people feel full sooner and think about food less. Some notice this within the first few days.

Digestive changes

Nausea, diarrhea, constipation, and a heavy or full feeling are the most common side effects. They are usually mild to moderate and most common during the first weeks and after dose increases.

Lower energy or headaches

Eating and drinking less can leave you tired or headachy. Fluids and regular small meals often help. See headaches on GLP-1 medications and GLP-1 fatigue.

How to prepare

• Stock easy foods. Yogurt, eggs, broth-based soups, crackers, bananas, rice, and lean proteins are good to have on hand.
• Plan smaller meals. Eat slowly and stop at the first sign of fullness.
• Set up a hydration habit. Keep a water bottle nearby and sip through the day. Add electrolytes if you are eating very little or have diarrhea.
• Have fiber ready. Gentle fiber foods, added slowly, help prevent constipation.
• Prioritize protein. Include a protein source at every meal, even when portions are small.
• Keep a simple log. Note how you feel, what you ate, and your injection day. It helps you and your prescriber spot patterns.

When to call your doctor

Mild side effects are expected. Contact your healthcare provider right away if you have:

• Severe pain in your stomach or upper abdomen that does not go away, with or without vomiting
• Vomiting or diarrhea that keeps you from holding down fluids
• Signs of dehydration, like dizziness, very dark urine, or rarely urinating
• Signs of an allergic reaction, such as swelling of the face, lips, or throat, or trouble breathing (seek emergency care)
• If you have diabetes, signs of low blood sugar such as shakiness, sweating, or confusion

Where Alula fits

The first weeks are often when eating and drinking enough is hardest. Alula is a daily drink mix designed for people on GLP-1 medications. Each stick includes electrolytes (350 mg sodium, 220 mg potassium, and 130 mg magnesium), 1,500 mg of calcium HMB, 2 g of collagen peptides, 2 g of PHGG fiber, a Bacillus coagulans probiotic (about 2 billion CFU), 250 mg of ginger root extract, and a full panel of vitamins and minerals, to support hydration, digestive comfort, and daily nutrient intake while your body adjusts.* Learn more about Alula.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Alula is a dietary supplement, not a GLP-1 medication. Talk with your healthcare provider before starting any new supplement.

Frequently asked questions

How soon will I notice my appetite change?

Some people notice within days, others over a few weeks. Starting doses are low, so changes are often gradual.

Are side effects worse in the first week?

Digestive side effects are most common early in treatment and after each dose increase. For many people they ease as the body adjusts.

Should I change my diet before starting?

You don't need a dramatic change. Having easy, protein-rich foods and a hydration plan ready makes the first weeks smoother.